Not all placental allograftsare created equal
The differences in preservation matter
Placental allografts have been used for over a century—the fetal membrane was first used for the transplantation of skin in 1910.1 As innovations were made over time, the preservation methods can vary with each commercially available product.
Some manufacturers remove part of the placental membrane—including the amnion, chorion, epithelium, or spongy layer—which also removes important components and alters the native tissue composition.2
The more a placental allograft is processed, including the removal of layers, the more limited the ECM protein content for use as a protective barrier. Preserving more layers retains the native tissue composition including structural proteins for use as a protective barrier.
Properties of human amnion and chorion6
| Property | Amnion | Chorion supporting use as a protective barrier |
|---|---|---|
| Extracellular matrix (ECM): structural matrix | Collagens I, III, IV, V, VI, elastin | Collagens I, III, IV, V, VI, tropoelastin |
| ECM: glycoproteins | Fibronectin, laminins, nidogen | Fibronectin, laminins, nidogen |
| ECM: proteoglycans | Chondroitin, dermatan sulfate, hyaluronan, decorin, biglycan | Chondroitin, dermatan sulfate, hyaluronan, decorin, biglycan, versican, perlican |
NuShield protects wounds to provide a healing environment
Discover the native layers of NuShield, or contact an Organogenesis Tissue Regeneration Specialist to see how NuShield can help protects wounds to provide a favorable environment for healing across different wound types.
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REFERENCES:
- Niknejad H, et al. Eur Cells Mater. 2008;15:88-99.
- Koob TJ, et al. J Biomed Mater Res B Appl Biomater. 2014;102(6):1353-1362.
- McQuilling JP, et al. Wounds. 2017;29(6):E38-E42.
- McQuilling JP, et al. Int Wound J. 2017;14(6):993-1005.
- Abshier S. Podiatry Today. 2015;28(11):20-26.
- Brantley JN, et al. Adv Wound Care. 2015;4(9):545-559.